Week 9 prediction · Updated November 5, 2026
Buffalo Bills vs San Francisco 49ers
The Power Index projects the Buffalo Bills to win by about 5 points.
Projection
Buffalo Bills
No. 1 · 6-1
68%
San Francisco 49ers
No. 2 · 6-1
32%
VS
Tale of the tape
Buffalo Bills
- Record
- 6-1
- Index score
- 95.7
- Super Bowl LXI odds
- +450
- Rank
- No. 1
Key driver: Top ranked league offense
San Francisco 49ers
- Record
- 6-1
- Index score
- 89.1
- Super Bowl LXI odds
- +500
- Rank
- No. 2
Key driver: Leading NFC West with a balanced roster
Frequently asked questions
Who would win Buffalo Bills vs San Francisco 49ers?
The Week 9 Power Index projects the Buffalo Bills to beat the San Francisco 49ers by about 5 points, with a 68% win probability.
Which team is ranked higher, the Bills or the 49ers?
The Buffalo Bills are No. 1 (6-1) and the San Francisco 49ers are No. 2 (6-1) in the Week 9 NFL Power Index.
What are the Super Bowl LXI odds for the Bills and 49ers?
The Buffalo Bills are +450 and the San Francisco 49ers are +500 to win Super Bowl LXI.